Discover Aerogen Solo from Aerogen – a world leader in acute care aerosol drug delivery†1
Discover how the Aerogen Solo can support aerosol drug delivery at every stage of a patient's respiratory journey: during invasive mechanical ventilation (IMV) and non-invasive supports such as non-invasive ventilation (NIV), high-flow (HF) therapies and when self-ventilating (SV).2
†Global market presence in 75+ countries worldwide
- Quick and easy to set up2
- Virtually silent2
- Single patient use2
- 28 days intermittent or 7 days continuous use2
- No added flow2
- Refill medication cup without opening the circuit2
- 6 mL cup2
- Can be placed at the wye or at the humidifier2
How it works
The core of Aerogen’s success is a unique palladium vibrating mesh creating ideal particle size for delivering inhaled medication into the lungs.1,12
Aerogen Ultra with a face mask for EMS use: set-up guide
Aerogen Ultra with mouthpiece for EMS use: set-up guide
Aerogen Solo on a NIV single-limb circuit for EMS use: set-up guide
Aerogen Solo on the dry side of the humidifier: set-up guide
Aerogen Solo for adult nasal high-flow: set-up guide
Aerogen Solo for paediatric nasal high-flow: set-up guide
Aerogen Solo at the wye: set-up guide
Aerogen Continuous Nebulisation Tube: set-up guide
Aerogen Ultra: set-up guide
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Aerogen Solo at the wye for hospital and homecare use: set-up guide
Aerogen Solo for adult high-flow for hospital and homecare use: set-up guide
Aerogen Solo at the dry side of the humidifier for hospital and homecare use: set-up guide
Aerogen Solo at the wye for EMS use: set-up guide
Aerogen Solo for adult high-flow for EMS use: set-up guide
Aerogen Solo on the dry side of the humidifier for EMS use: set-up guide
I have a medical/clinical query, or my query is not addressed below. Who can I contact for medical or clinical information related to the use of Aerogen products?
Please contact Aerogen Medical Affairs directly for medical information/published clinical research regarding the use of Aerogen products. Email: MedicalScience@aerogen.com (US/Canada/LATAM) or email@example.com (all other countries).
What medications can be used with the Aerogen Solo, Aerogen Pro?
The Aerogen Solo & Aerogen Pro should be used with physician prescribed medications for inhalation which are approved for use with a general purpose nebuliser.¹ Should you require information on a whether a medication is approved for inhalation please contact the medication manufacturer directly.
Should I adjust the drug dosage when I’m using the Aerogen Solo, Aerogen Pro?
Information on drug dosing must be sourced from the manufacturer’s approved prescribing information for the inhaled formulation. Aerogen Ltd cannot provide specific advice on medication dose.
Is the drug affected if it causes discoloration of the water in a humidifier?
Occasionally, a change in the colour of the water in a heated humidifier has been noted with certain medications if aerosolized proximal to the humidifier. Should you have concerns related to a specific medication please do not hesitate to contact the Medical Affairs team at the email addresses listed above for assistance. The treating clinician should always consider a medications SPC and/or consult with a pharmacist/hospital pharmacy to determine whether placement proximal to the humidifier is suitable for a given therapeutic. Aerogen devices are approved for use in a number of positions offering the treating health care professional a range of placement options if discoloration is a concern. These positions are detailed in the directions for use documents which are accessible on the website.¹
What do I do if crystals form in the nebuliser chamber?
Any medication that has a high ionic concentration, for instance hypertonic saline solutions, if permitted to dry on the Aerogen Vibronic aerosol generator in the nebuliser chamber, may form visible crystals. In the event where crystallisation is observed in the Aerogen Solo, Aerogen recommend to aerosolise a few drops of normal saline solution to clear any residual crystallisation.
How do you remove residue in the chamber after nebulisation of viscous drugs?
Should you wish to remove any viscous drug residues from the Aerogen Solo medication reservoir you may nebulise a few drops of normal saline.
What effect does bias ventilator flow have on aerosol output and deposition?
The impact of bias ventilator flow on aerosol deposition depends on the location of the aerosol generator in the circuit. An in vitro study by Ari et al., (2010) assessing aerosol delivery during mechanical ventilation in the presence of bias flow determined that optimal aerosol deposition may be achieved by nebuliser placement on the dry side of humidifier. Similarly, Berlinski & Willis (2013) demonstrated in a paediatric model, that in the presence of bias flow, nebulisers were more effective when placed back at the humidifier as compared to closer to the wye.²⁻³ In the absence of bias flow optimal deposition was observed when the nebuliser was placed at or close to the wye in this adult model.⁴
Can you use a Heat and Moisture Exchange Device (with filter) (HME/HMEF) while delivering aerosol with the Aerogen Solo?
Yes, the Aerogen Solo is approved for use with a HME.¹ The Aerogen Solo should be placed between the patient and HME as detailed in the Aerogen Solo directions for use.¹ Note: Only a HME/HMEf approved for use with a nebuliser should be used. Follow the HME/HMEf manufacturer instructions regarding use with a nebuliser. Ensure the combination of nebuliser, T-piece and HME/HMEf volumes are suitable for the tidal volume being delivered, according to the patient size.
What are the advantages of Aerogen vibrating mesh nebulisers (VMN) compared with other nebulisers, or inhalers for adult and pediatric patients?
Aerogen vibrating mesh nebulisers are electrically powered, quiet and require no additional flow or pressure to operate, ensure a minimal residual volume and are suitable for use with physician prescribed solutions that are approved for use with a general-purpose nebulisers.¹ A narrative review by Lin et al. compared VMN with other, similar, during invasive mechanical ventilation.⁵
Can you deliver an effective dose with the Aerogen Solo to an adult patient during High flow therapy?
Both in vitro and in vivo studies have examined aerosol delivery efficiency via Aerogen devices concurrent with High Flow Nasal Oxygen therapy with adult models/patients⁶⁻¹⁰ These studies suggest that an effective dose may be delivered during concurrent High Flow Nasal Oxygen therapy and medication aerosolisation via the Aerogen Solo.⁶⁻¹⁰
Do different ventilator parameters affect aerosol delivery?
Yes, a range of ventilator parameters; including flow, inspiratory time (duty cycle), ventilatory mode, timing of nebulisation and circuit features; tube sizes, heat, and humidification, can affect aerosol delivery in mechanically ventilated patients.2,11-13 Reviews by Dr. Dhanani and others summarise the impact of these features on aerosol delivery.11,13
I have a medical/clinical query or my query is not addressed below. Who can I contact for medical or clinical information related to the use of Aerogen products?
Please contact Aerogen Medical Affairs directly for medical information/published clinical research regarding the use of Aerogen products please email: MedicalScience@aerogen.com (US/Canada/LATAM) or firstname.lastname@example.org (all other countries).
What brands or models of ventilators can use the Aerogen Solo?
The Aerogen Solo can be used with any brand or model of ventilator by positioning in the circuit as detailed in the directions for use.¹ As well as these approved positions, Aerogen technology is integrated within ventilators made by Hamilton Medical, Maquet, and GE Healthcare.
How long does it take to deliver a unit dose?
The minimum flow rate of the Aerogen Solo is >0.2ml/min with an average of 0.38ml/min.¹ A typical 3 ml dose would therefore take about 7 minutes to aerosolise. Note, the flow rate through the nebuliser is constant and cannot be changed on a graphical user interface of a ventilator. Dosimetric/volumetric or titrated delivery of medication is possible if the Aerogen Solo is used with the Aerogen continuous nebulisation tube set (CNTS).¹
How much medication is left at the end of a treatment?
Medication left in the nebuliser at the end of the treatment is minimal: < 0.1mL.¹
How much medication can be given at one time?
The medication cup reservoir of the Aerogen Solo can hold up to 6 mL.¹ Alternatively, a suitable syringe can be used with the Aerogen CNTS and Aerogen Solo for volumetric (drop-by-drop) continuous delivery of medication.¹
Can the Aerogen Solo be used with a mouthpiece and an aerosol mask?
Yes, the Aerogen Solo can be connected to the Aerogen Ultra (a valved holding chamber adapter into which the Aerogen Solo can integrate) and used with a mouthpiece or aerosol mask.¹
How much noise is generated when using the Aerogen Solo?
The Aerogen Solo operates with a noise level of less than 35dB measured at 1 m distance.¹ This is close to the average sound level of a soft whisper.14
How do you remove residue in the chamber after nebulisation of viscous drugs?
Medication residue of viscous drugs in the Aerogen Solo reservoir can be removed by nebulising a few drops of normal saline.
What medications can the Aerogen Solo deliver?
The Aerogen Solo & Aerogen Pro should be used with physician prescribed medications for inhalation which are approved for use with a general-purpose nebuliser. Should you require information on a whether a medication is approved for inhalation please contact the medication manufacturer directly.
Can I use the same Aerogen Solo device to deliver different drug types?
In principle, yes, the same Aerogen Solo device may be used to deliver different drug types to the same patient. (Note the Aerogen Solo is a single patient device). Please consult your pharmacist, the therapeutic agents summary of product characteristics and/or your hospital’s policy before combining any medications.
What is the lifespan of use of a single Aerogen Solo device?
The Aerogen Solo is a single patient use device. The life of the nebuliser has been validated and approved for a typical usage profile of 4 treatments per day, using the 30-minute mode, for a maximum of 28 days.1 When used in continuous mode the life of the nebuliser has been approved and validated for a maximum of 7 days.¹ In independent research Lin et al. (2020) assessed the reliability of Aerogen VMN to deliver treatments 3 times a day at intervals of 6 hours for 28 days, without cleaning between tests.15 The performance of the Aerogen Solo (inhaled drug dose, residual dose, particle size and nebulisation time) was similar across the 28 days of use.15
How does the lung deposition of drugs with the Aerogen Solo compare to standard nebulisers?
A number of in vivo studies have included a comparator device when examining pulmonary drug delivery with the Aerogen Solo.16–20 These investigators reported aerosol drug delivery was between 2-6 times greater from an Aerogen Solo than from the comparator devices, depending on modality and application.16–20
What should I do if the Aerogen Solo stops nebulising?
Please refer to the trouble shooting guide in the directions for use.¹
How do I get replacement parts?
Contact your local Aerogen Solo Distributor. (Refer to https://www.aerogen.com/distributors/)
Will the Aerogen Solo affect the expiratory flow sensor and expiratory filter?
It is standard clinical practice, and recommended, to position a filter at the expiratory limb during mechanical ventilation when delivering aerosolized medication through the circuit.13,21–23 The addition of aerosolised medication to a ventilator circuit could potentially affect the expiratory filter and consequently the flow sensor due to the increase in moisture in the circuit and increased resistance.24 Consult your ventilator manufacturer’s instructions for use for information on the necessary precautions to take when delivering aerosolized medication through a ventilator circuit and the use of an expiratory limb filter. It is recommended to monitor expiratory filters if delivering aerosolized medication, check the filter if expiratory resistance is increased, and to change the filters as directed by the manufacturer.13,22,24
What should I do if the expiratory filter becomes saturated causing the ventilator to alarm following nebulisation?
You should consult your ventilator manufacturer’s instructions for guidance on expiratory limb filters and associated alarms. Any aerosol added to a ventilator circuit could affect the expiratory flow and the expiratory filter as moisture in the circuit is increased.24 When aerosolising medication through a circuit the expiratory filter should be monitored as well as the patients’ expiratory resistance. Changing the filter may be required on a regular basis and should be undertaken according to the manufacturer’s recommendations.13,24
Can the Aerogen Solo be used during Non-Invasive Ventilation?
Yes, the Aerogen Solo during can be used during non-invasive ventilation.¹
Can the Aerogen Solo be used with neonatal ventilators containing proximal flow sensors?
Please refer to your ventilator manufacturer’s instructions for use.¹ Note: The Aerogen Solo system is not approved for use with neonates (<29 days old) in the USA.25
Where do you place the Aerogen Solo with neonate patients?
The Aerogen Solo can connect to neonate breathing circuits and positioned approximately 30 cm back from the patient wye as detailed in the Aerogen Solo directions for use.1 It may also be positioned on the dry side of the humidifier. Note: The Aerogen Solo system is not approved for use with neonates (<29 days old) in the USA.25